Mast Cell Activation Disease (MCAD) or Mast Cell Activation Syndrome (MCAS) is a rare condition characterized by the presence of hyperactive mast cells that release excessive amounts of inflammatory and allergic mediators. MCAD is associated with a wide range of clinical symptoms (please see below). Secondary MCAD, or reactions caused by other reactive processes such as drugs and infections, can also occur in certain patients. The underlying cause of mast cell activation is clonal mast cells (MCS) however the diagnosis of MCAD remains challenging due to the need to exclude other relevant diagnoses such as neuroendocrine conditions, mastocytosis, or other causes of chronic multisystem conditions.
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